Mouse Anti-DLX3 Recombinant Antibody (4F8) (V2LY-0425-LY520)

Name: Mouse Anti-DLX3 Recombinant Antibody (4F8)
SKU: V2LY-0425-LY520
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4F8

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

DLX3 full-length recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Distal-Less Homeobox 3

Entrez Gene ID

1747

UniProt ID

O60479

Function

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Biological Process

Blood vessel development Source: Ensembl
Cell differentiation Source: GO_Central
Epithelial cell differentiation Source: GO_Central
Odontoblast differentiation Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Placenta development Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Trichodentoosseous syndrome (TDO):
An autosomal dominant disease characterized by curly kinky hair at birth, enamel hypoplasia, taurodontism, thickening of cortical bones and variable expression of craniofacial morphology.
Amelogenesis imperfecta 4 (AI4):
An autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Enamel is thin, teeth are small and widely spaced.

More Infomation

References

Hou, F., Jin, H., Cao, L., Jiao, X., Wang, B., Liu, H., & Cui, B. (2022). The Imbalance Expression of DLX3 May Perform Critical Function in the Occurrence and Progression of Preeclampsia. Computational and Mathematical Methods in Medicine, 2022.

Li, J., Lin, Q., Lin, Y., Lai, R., & Zhang, W. (2021). Effects of DLX3 on the osteogenic differentiation of induced pluripotent stem cell‑derived mesenchymal stem cells. Molecular Medicine Reports, 23(4), 1-1.

Qadir, A. S., Lee, J., Lee, Y. S., Woo, K. M., Ryoo, H. M., & Baek, J. H. (2019). Distal‐less homeobox 3, a negative regulator of myogenesis, is downregulated by microRNA‐133. Journal of Cellular Biochemistry, 120(2), 2226-2235.

Sun, S., Yu, M., Fan, Z., Yeh, I. T., Feng, H., Liu, H., & Han, D. (2019). DLX3 regulates osteogenic differentiation of bone marrow mesenchymal stem cells via Wnt/β-catenin pathway mediated histone methylation of DKK4. Biochemical and biophysical research communications, 516(1), 171-176.

Chiu, Y. H., Yang, M. R., Wang, L. J., Chen, M. H., Chang, G. D., & Chen, H. (2018). New insights into the regulation of placental growth factor gene expression by the transcription factors GCM1 and DLX3 in human placenta. Journal of Biological Chemistry, 293(25), 9801-9811.

Zeng, L., Zhao, N., Li, F., Han, D., Liu, Y., Liu, H., ... & Feng, H. (2018). miR-675 promotes odontogenic differentiation of human dental pulp cells by epigenetic regulation of DLX3. Experimental Cell Research, 367(1), 104-111.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DLX3 Recombinant Antibody (4F8)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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