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Rabbit Anti-DLX4 Recombinant Antibody (EG971) (CBMAB-EN1153-LY)

The product is antibody recognizes DLX4. The antibody EG971 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:1000.
See all DLX4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG971
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from C-terminal of human DLX4.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Distal-Less Homeobox 4
Introduction
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]
Entrez Gene ID
1748
UniProt ID
Q92988
Alternative Names
Distal-Less Homeobox 4; Homeobox Protein DLX-7; Homeobox Protein DLX-8; Beta Protein 1; DLX7; DLX9; DLX8;
Function
May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.
Biological Process
Cell differentiation Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Non-syndromic orofacial cleft 15 (OFC15):
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC15 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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