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Mouse Anti-DNAJB2 Recombinant Antibody (2C9) (CBMAB-D1287-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DnaJ Heat Shock Protein Family (Hsp40) Member B2 (DNAJB2). The antibody can be used for immunoassay techniques, such as ELISA, IF, IHC-P, WB.
See all DNAJB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C9
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member B2
Introduction
DNAJB2 is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Entrez Gene ID
3300
UniProt ID
P25686
Alternative Names
DnaJ Heat Shock Protein Family (Hsp40) Member B2; DnaJ (Hsp40) Homolog, Subfamily B, Member 2; Heat Shock 40 KDa Protein 3; Heat Shock Protein J1; HSJ-1; HSPF3; HSJ1;
Function
Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199).

In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540).

Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695).

Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278).
Biological Process
Chaperone-mediated protein folding Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of inclusion body assembly Source: BHF-UCL
Negative regulation of protein binding Source: UniProtKB
Negative regulation of protein deubiquitination Source: BHF-UCL
Neuron cellular homeostasis Source: ARUK-UCL
Positive regulation of ATPase activity Source: UniProtKB
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
Positive regulation of protein ubiquitination Source: BHF-UCL
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein refolding Source: UniProtKB
Regulation of chaperone-mediated protein folding Source: UniProtKB
Regulation of protein localization Source: ParkinsonsUK-UCL
Regulation of protein ubiquitination Source: UniProtKB
Response to unfolded protein Source: ProtInc
Ubiquitin-dependent ERAD pathway Source: BHF-UCL
Cellular Location
Isoform 1: Endoplasmic reticulum membrane
Isoform 2: Cytoplasm; Nucleus
Involvement in disease
Distal spinal muscular atrophy, autosomal recessive, 5 (DSMA5):
An autosomal recessive neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and atrophy resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. Sensation and cognition are not impaired.
PTM
Ubiquitinated by STUB1; does not lead to proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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