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Mouse Anti-DNAJB2 Recombinant Antibody (CF136) (CBMAB-FT330LY)

The product is antibody recognizes DNAJB2 . The antibody CF136 immunoassay techniques such as: ELISA, WB.
See all DNAJB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CF136
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
DnaJ (Hsp40) homolog, subfamily B, member 2
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member B2
Entrez Gene ID
Human3300
Mouse56812
UniProt ID
HumanP25686
MouseQ9QYI5
Alternative Names
HSJ1, HSPF3
Function
Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199).

In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540).

Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695).

Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278).
Biological Process
Chaperone-mediated protein folding Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of inclusion body assembly Source: BHF-UCL
Negative regulation of protein binding Source: UniProtKB
Negative regulation of protein deubiquitination Source: BHF-UCL
Neuron cellular homeostasis Source: ARUK-UCL
Positive regulation of ATPase activity Source: UniProtKB
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
Positive regulation of protein ubiquitination Source: BHF-UCL
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein refolding Source: UniProtKB
Regulation of chaperone-mediated protein folding Source: UniProtKB
Regulation of protein localization Source: ParkinsonsUK-UCL
Regulation of protein ubiquitination Source: UniProtKB
Response to unfolded protein Source: ProtInc
Ubiquitin-dependent ERAD pathway Source: BHF-UCL
Cellular Location
Isoform 1: Endoplasmic reticulum membrane
Isoform 2: Cytoplasm; Nucleus
Involvement in disease
Distal spinal muscular atrophy, autosomal recessive, 5 (DSMA5):
An autosomal recessive neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and atrophy resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. Sensation and cognition are not impaired.
PTM
Ubiquitinated by STUB1; does not lead to proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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