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Mouse Anti-DTD2 Recombinant Antibody (7B8) (CBMAB-A0932-LY)

The product is antibody recognizes C14orf126. The antibody 7B8 immunoassay techniques such as: sELISA, ELISA.
See all DTD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7B8
Antibody Isotype
IgG2b, κ
Application
sELISA, ELISA

Basic Information

Immunogen
C14orf126 (NP_542395.1, 1 a.a. ~ 168 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
D-Tyrosyl-TRNA Deacylase 2 (Putative)
Entrez Gene ID
112487
UniProt ID
Q96FN9
Alternative Names
MGC9912
Research Area
Deacylates mischarged D-aminoacyl-tRNAs (By similarity).

Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity).

Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity).

Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity).

By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408).

Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408).

Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity).
Biological Process
Aminoacyl-tRNA metabolism involved in translational fidelity Source: UniProtKB
tRNA metabolic process Source: GO_Central
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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