DTD2

DTD2 (D-Tyrosyl-TRNA Deacylase 2 (Putative)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and D-tyrosyl-tRNA(Tyr) deacylase activity. An important paralog of this gene is ENSG00000203546.

D-Tyrosyl-TRNA Deacylase 2 (Putative)

Deacylates mischarged D-aminoacyl-tRNAs (By similarity).

Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity).

Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity).

Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity).

By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408).

Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408).

Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity).

Aminoacyl-tRNA metabolism involved in translational fidelity Source: UniProtKB
tRNA metabolic process Source: GO_Central

Cytoplasm