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Mouse Anti-DTD2 Recombinant Antibody (CBYCD-433) (CBMAB-D1832-YC)

Provided herein is a Mouse monoclonal antibody, which binds to D-Tyrosyl-TRNA Deacylase 2 (Putative) (DTD2). The antibody can be used for immunoassay techniques, such as ELISA.
See all DTD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-433
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
D-Tyrosyl-TRNA Deacylase 2 (Putative)
Introduction
DTD2 (D-Tyrosyl-TRNA Deacylase 2 (Putative)) is a protein coding gene. It has proved that the protein has hydrolase activity, acting on ester bonds and D-tyrosyl-tRNA(Tyr) deacylase activity. And a paralog is ENSG00000203546.
Entrez Gene ID
112487
UniProt ID
Q96FN9
Alternative Names
D-Tyrosyl-TRNA Deacylase 2 (Putative); Putative D-Tyrosyl-TRNA Deacylase 2; C14orf126; Probable D-Tyrosyl-TRNA(Tyr) Deacylase 2; Putative D-Tyrosyl-TRNA(Tyr) Deacylase 2; Chromosome 14 Open Reading Frame 126; EC 3.1.-.-;
Research Area
Deacylates mischarged D-aminoacyl-tRNAs (By similarity).

Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity).

Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity).

Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity).

By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408).

Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408).

Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity).
Biological Process
Aminoacyl-tRNA metabolism involved in translational fidelity Source: UniProtKB
tRNA metabolic process Source: GO_Central
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

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