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Mouse Anti-DYNLL2 Recombinant Antibody (74.1) (CBMAB-D2008-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dynein Light Chain LC8-Type 2 (DYNLL2). The antibody can be used for immunoassay techniques, such as FC, ICC, IF, IP, WB.
See all DYNLL2 antibodies
Published Data
Fig.1 Western blot analysis of co-precipitated dynein, kinesin and Hsc70 detected with mouse monoclonal antibodies against dynein.
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Fig.2 For the detection of native HDGF-C and its subcellular localization, affinity purified rabbit antibodies raised against dynein.
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Summary

Host Animal
Mouse
Specificity
Human, Pig, Rat, Sheep, Cattle
Clone
74.1
Antibody Isotype
IgG
Application
FC, ICC, IF, IP, WB

Basic Information

Immunogen
Purified bovine brain cytoplasmic dynein
Specificity
Human, Pig, Rat, Sheep, Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dynein Light Chain LC8-Type 2
Introduction
DYNLL2 (Dynein Light Chain LC8-Type 2) is a protein coding gene. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Transport to the Golgi and subsequent modification. It has proved that the protein has motor activity and cytoskeletal protein binding. And a paralog is DYNLL1.
Entrez Gene ID
Human140735
Pig100512860
Rat140734
Sheep101121274
Cattle540369
UniProt ID
HumanQ96FJ2
PigF2Z536
RatQ78P75
SheepW5PEV7
CattleQ3MHR3
Alternative Names
Dynein Light Chain LC8-Type 2; 8 KDa Dynein Light Chain B; DLC8b; Dlc2; Radial Spoke 22 Homolog (Chlamydomonas); Dynein Light Chain 2, Cytoplasmic; Radial Spoke 22 Homolog; DNCL1B; RSPH22;
Research Area
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).
Biological Process
Cilium assembly Source: GO_Central
Microtubule-based process Source: InterPro
Positive regulation of ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
Cellular Location
Cytoskeleton
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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