Sign in or Register   Sign in or Register
  |  

Mouse Anti-EEF1D Recombinant Antibody (CBFYE-0463) (CBMAB-E0800-FY)

This product is mouse antibody that recognizes EEF1D. The antibody CBFYE-0463 can be used for immunoassay techniques such as: ELISA, WB, IHC, IF.
See all EEF1D antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYE-0463
Antibody Isotype
IgG1
Application
ELISA, WB, IHC, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Eukaryotic Translation Elongation Factor 1 Delta
Introduction
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.
Entrez Gene ID
Human1936
Mouse66656
Rat300033
UniProt ID
HumanP29692
MouseP57776
RatQ68FR9
Alternative Names
Eukaryotic Translation Elongation Factor 1 Delta; Eukaryotic Translation Elongation Factor 1 Delta (Guanine Nucleotide Exchange Protein); Antigen NY-CO-4; EF-1-Delta; EF1D; Elongation Factor 1-Delta; FP1047; EF-1D
Research Area
Isoform 1:
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.

Isoform 2:
Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
Biological Process
Cellular response to ionizing radiation Source: UniProtKB
mRNA transcription Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Regulation of cell death Source: UniProtKB
Translational elongation Source: GO_Central
Cellular Location
Isoform 2: Nucleus

Xu, Q., Liu, Y., Wang, S., Wang, J., Liu, L., Xu, Y., & Qin, Y. (2022). Interfering with the expression of EEF1D gene enhances the sensitivity of ovarian cancer cells to cisplatin. BMC cancer, 22(1), 1-15.

Xu, H., Yu, S., Peng, K., Gao, L., Chen, S., Shen, Z., ... & Kang, M. (2021). The role of EEF1D in disease pathogenesis: a narrative review. Annals of Translational Medicine, 9(20).

Hou, Y., Xie, Y., Yang, S., Han, B., Shi, L., Bai, X., ... & Sun, D. (2021). EEF1D facilitates milk lipid synthesis by regulation of PI3K‐Akt signaling in mammals. The FASEB Journal, 35(5), e21455.

Xie, C., Zhou, M., Lin, J., Wu, Z., Ding, S., Luo, J., ... & Song, Y. (2020). EEF1D promotes glioma proliferation, migration, and invasion through EMT and PI3K/Akt pathway. BioMed Research International, 2020.

BİTERGE SÜT, B., & İKİNCİ KELEŞ, A. (2020). Prognostic and Predictive Significance of Eukaryotic Elongation Factor 1D (eEF1D) in Breast Cancer: A Potential Marker of Response to Endocrine Therapy. Oncologie, 22(3).

Ugur Iseri, S. A., Yucesan, E., Tuncer, F. N., Calik, M., Kesim, Y., Altiokka Uzun, G., & Ozbek, U. (2019). Biallelic loss of EEF1D function links heat shock response pathway to autosomal recessive intellectual disability. Journal of Human Genetics, 64(5), 421-426.

Cheng, D. D., Li, S. J., Zhu, B., Zhou, S. M., & Yang, Q. C. (2018). EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling. Journal of Experimental & Clinical Cancer Research, 37(1), 1-10.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-EEF1D Recombinant Antibody (CBFYE-0463)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare