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Rabbit Anti-EFNA3 Recombinant Antibody (EG1039) (CBMAB-EN1224-LY)

The product is antibody recognizes EFNA3. The antibody EG1039 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all EFNA3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1039
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from C-terminal of human EFNA3.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ephrin A3
Introduction
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human1944
Mouse13638
Rat170901
UniProt ID
HumanP52797
MouseO08545
RatA0A0G2JV56
Alternative Names
Ephrin A3; EHK1 Ligand; Ephrin-A3; Ehk1-L; LERK-3; EPLG3; EFL-2;
Research Area
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
Biological Process
Axon guidance Source: GO_Central
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: ARUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: ARUK-UCL
Cellular Location
Cell membrane

Zhuang, Y., Cheng, M., Li, M., Cui, J., Huang, J., Zhang, C., ... & Yu, H. (2022). Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway. Acta Biomaterialia.

Jiang, B., Yang, K., Tang, C., Chen, R., & Wang, C. (2022). LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis. Bioengineered, 13(4), 8995-9006.

Dong, C., Li, P., Wu, Y., Guo, Z., & He, R. (2022). The 1q21. 3 region driver gene EFNA3 promotes disease progression via inhibition of lung adenocarcinoma cell apoptosis. Translational Cancer Research, 11(5), 1309.

Lin, P., & Yang, H. (2022). EFNA3 is a prognostic biomarker for the overall survival of hepatocellular carcinoma patients. Journal of Hepatology.

Deng, M., Tong, R., Zhang, Z., Wang, T., Liang, C., Zhou, X., & Hou, G. (2021). EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma. Cancer Cell International, 21(1), 1-17.

Wang, H., Wang, L., Zhou, X., Luo, X., Liu, K., Jiang, E., ... & Shang, Z. (2020). OSCC exosomes regulate miR-210-3p targeting EFNA3 to promote oral cancer angiogenesis through the PI3K/AKT pathway. BioMed research international, 2020.

Husain, A., Chiu, Y. T., Ho, D. W., Sze, K. M., Chan, L. K., Tsui, Y. M., ... & Ng, I. O. (2018). EFNA3, a key functional mediator of hypoxic microenvironment in hepatocellular carcinoma. Cancer Research, 78(13_Supplement), 2431-2431.

Shukla, A., Dahiya, S., Onteru, S. K., & Singh, D. (2018). Differentially expressed miRNA‐210 during follicular‐luteal transition regulates pre‐ovulatory granulosa cell function targeting HRas and EFNA3. Journal of Cellular Biochemistry, 119(10), 7934-7943.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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