EFNA3
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]
Full Name
Ephrin A3
Research Area
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
Biological Process
Axon guidance Source: GO_Central
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: ARUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: ARUK-UCL
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: ARUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: ARUK-UCL
Cellular Location
Cell membrane
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Anti-EFNA3 antibodies
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Target: EFNA3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-205
Tag: His Tag
Target: EFNA3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-213
Tag: His Tag
Target: EFNA3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-213
Tag: hFc Tag
Target: EFNA3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-213
Target: EFNA3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYE-0494
Application*: E, IP
Target: EFNA3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0493
Application*: E, IP
Target: EFNA3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0492
Application*: WB, IP, IF, E
Target: EFNA3
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle
Clone: CBFYE-0491
Application*: WB, IP, IF, E
Target: EFNA3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: E0843
Application*: WB, IH
Target: EFNA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-0495
Application*: E
Target: EFNA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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