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Mouse Anti-EFNA3 Recombinant Antibody (E0843) (V2LY-0425-LY1508)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
E0843
Antibody Isotype
IgG2
Application
WB, IHC

Basic Information

Immunogen
Human recombinant Ephrin-A3 (extracellular domain).
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:1,000
IHC15 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Trehalose & PBS
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ephrin A3
Entrez Gene ID
1944
UniProt ID
P52797
Research Area
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
Biological Process
Axon guidance Source: GO_Central
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: ARUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: ARUK-UCL
Cellular Location
Cell membrane
More Infomation

Zhuang, Y., Cheng, M., Li, M., Cui, J., Huang, J., Zhang, C., ... & Yu, H. (2022). Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway. Acta Biomaterialia.

Jiang, B., Yang, K., Tang, C., Chen, R., & Wang, C. (2022). LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis. Bioengineered, 13(4), 8995-9006.

Dong, C., Li, P., Wu, Y., Guo, Z., & He, R. (2022). The 1q21. 3 region driver gene EFNA3 promotes disease progression via inhibition of lung adenocarcinoma cell apoptosis. Translational Cancer Research, 11(5), 1309.

Lin, P., & Yang, H. (2022). EFNA3 is a prognostic biomarker for the overall survival of hepatocellular carcinoma patients. Journal of Hepatology.

Deng, M., Tong, R., Zhang, Z., Wang, T., Liang, C., Zhou, X., & Hou, G. (2021). EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma. Cancer Cell International, 21(1), 1-17.

Wang, H., Wang, L., Zhou, X., Luo, X., Liu, K., Jiang, E., ... & Shang, Z. (2020). OSCC exosomes regulate miR-210-3p targeting EFNA3 to promote oral cancer angiogenesis through the PI3K/AKT pathway. BioMed research international, 2020.

Husain, A., Chiu, Y. T., Ho, D. W., Sze, K. M., Chan, L. K., Tsui, Y. M., ... & Ng, I. O. (2018). EFNA3, a key functional mediator of hypoxic microenvironment in hepatocellular carcinoma. Cancer Research, 78(13_Supplement), 2431-2431.

Shukla, A., Dahiya, S., Onteru, S. K., & Singh, D. (2018). Differentially expressed miRNA‐210 during follicular‐luteal transition regulates pre‐ovulatory granulosa cell function targeting HRas and EFNA3. Journal of Cellular Biochemistry, 119(10), 7934-7943.

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For research use only. Not intended for any clinical use.

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