Mouse Anti-EFNA3 Recombinant Antibody (CBFYE-0495) (CBMAB-E0848-FY)

Name: Mouse Anti-EFNA3 Recombinant Antibody (CBFYE-0495)
SKU: CBMAB-E0848-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0495

Application

ELISA

Immunogen

Recombinant Human Ephrin-A3/EFNA3 Protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 23-214

More Infomation

Target

Full Name

Ephrin A3

Introduction

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin.

Entrez Gene ID

1944

UniProt ID

P52797

Alternative Names

Ephrin A3; EHK1 Ligand; Ephrin-A3; Ehk1-L; LERK-3; EPLG3; EFL-2

Research Area

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

Biological Process

Axon guidance Source: GO_Central
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: ARUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: ARUK-UCL

Cellular Location

Cell membrane

Zhuang, Y., Cheng, M., Li, M., Cui, J., Huang, J., Zhang, C., ... & Yu, H. (2022). Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway. Acta Biomaterialia.

Jiang, B., Yang, K., Tang, C., Chen, R., & Wang, C. (2022). LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis. Bioengineered, 13(4), 8995-9006.

Dong, C., Li, P., Wu, Y., Guo, Z., & He, R. (2022). The 1q21. 3 region driver gene EFNA3 promotes disease progression via inhibition of lung adenocarcinoma cell apoptosis. Translational Cancer Research, 11(5), 1309.

Lin, P., & Yang, H. (2022). EFNA3 is a prognostic biomarker for the overall survival of hepatocellular carcinoma patients. Journal of Hepatology.

Deng, M., Tong, R., Zhang, Z., Wang, T., Liang, C., Zhou, X., & Hou, G. (2021). EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma. Cancer Cell International, 21(1), 1-17.

Wang, H., Wang, L., Zhou, X., Luo, X., Liu, K., Jiang, E., ... & Shang, Z. (2020). OSCC exosomes regulate miR-210-3p targeting EFNA3 to promote oral cancer angiogenesis through the PI3K/AKT pathway. BioMed research international, 2020.

Husain, A., Chiu, Y. T., Ho, D. W., Sze, K. M., Chan, L. K., Tsui, Y. M., ... & Ng, I. O. (2018). EFNA3, a key functional mediator of hypoxic microenvironment in hepatocellular carcinoma. Cancer Research, 78(13_Supplement), 2431-2431.

Shukla, A., Dahiya, S., Onteru, S. K., & Singh, D. (2018). Differentially expressed miRNA‐210 during follicular‐luteal transition regulates pre‐ovulatory granulosa cell function targeting HRas and EFNA3. Journal of Cellular Biochemistry, 119(10), 7934-7943.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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