Human Recombinant EFNA3 protein (V2LY-0526-LY3914)

Name: Human Recombinant EFNA3 protein
SKU: V2LY-0526-LY3914
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Protein Construction

This product is Human Recombinant EFNA3 protein consist of Amino Acid: 1-213 and predicts a molecular mass of 22 kDa.

Molecule Mass

22 kDa

Sequence

Amino Acid: 1-213

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>70% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Ephrin A3

Research Area

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

Biological Process

Axon guidance Source: GO_Central
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: ARUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: ARUK-UCL

Cellular Location

Cell membrane

Zhuang, Y., Cheng, M., Li, M., Cui, J., Huang, J., Zhang, C., ... & Yu, H. (2022). Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway. Acta Biomaterialia.

Jiang, B., Yang, K., Tang, C., Chen, R., & Wang, C. (2022). LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis. Bioengineered, 13(4), 8995-9006.

Dong, C., Li, P., Wu, Y., Guo, Z., & He, R. (2022). The 1q21. 3 region driver gene EFNA3 promotes disease progression via inhibition of lung adenocarcinoma cell apoptosis. Translational Cancer Research, 11(5), 1309.

Lin, P., & Yang, H. (2022). EFNA3 is a prognostic biomarker for the overall survival of hepatocellular carcinoma patients. Journal of Hepatology.

Deng, M., Tong, R., Zhang, Z., Wang, T., Liang, C., Zhou, X., & Hou, G. (2021). EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma. Cancer Cell International, 21(1), 1-17.

Wang, H., Wang, L., Zhou, X., Luo, X., Liu, K., Jiang, E., ... & Shang, Z. (2020). OSCC exosomes regulate miR-210-3p targeting EFNA3 to promote oral cancer angiogenesis through the PI3K/AKT pathway. BioMed research international, 2020.

Husain, A., Chiu, Y. T., Ho, D. W., Sze, K. M., Chan, L. K., Tsui, Y. M., ... & Ng, I. O. (2018). EFNA3, a key functional mediator of hypoxic microenvironment in hepatocellular carcinoma. Cancer Research, 78(13_Supplement), 2431-2431.

Shukla, A., Dahiya, S., Onteru, S. K., & Singh, D. (2018). Differentially expressed miRNA‐210 during follicular‐luteal transition regulates pre‐ovulatory granulosa cell function targeting HRas and EFNA3. Journal of Cellular Biochemistry, 119(10), 7934-7943.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant EFNA3 protein, hFc Tag (CAT#: V2LY-0526-LY3915)

Human Recombinant EFNA3 protein, His Tag (CAT#: V2LY-0526-LY3916)

Mouse Recombinant EFNA3 protein, His Tag (CAT#: V2LY-0526-LY8260)

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Mouse Recombinant EFNA3 protein, His Tag (CAT#: V2LY-0526-LY8260)

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Mouse Anti-EFNA3 Recombinant Antibody (CBFYE-0491) (CAT#: V2LY-0425-LY1510)

Human Recombinant EFNA3 protein, His Tag (CAT#: V2LY-0526-LY3916)

Mouse Anti-EFNA3 Recombinant Antibody (CBFYE-0495) (CAT#: CBMAB-E0848-FY)

Mouse Anti-EFNA3 Recombinant Antibody (4) (CAT#: CBMAB-E0847-FY)

Mouse Anti-EFNA3 Recombinant Antibody (CBFYE-0493) (CAT#: V2LY-0425-LY1512)

Human Recombinant EFNA3 protein, hFc Tag (CAT#: V2LY-0526-LY3915)

Mouse Anti-EFNA3 Recombinant Antibody (E0843) (CAT#: V2LY-0425-LY1508)

Mouse Anti-EFNA3 Recombinant Antibody (CBFYE-0494) (CAT#: V2LY-0425-LY1513)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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