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Mouse Anti-EIF4EBP3 Recombinant Antibody (1E3) (CBMAB-1854CQ)

This product is a mouse monoclonal antibody that recognizes EIF4EBP3. The antibody 1E3 can be used for immunoassay techniques such as: ELISA, ICC, IF, WB.
See all EIF4EBP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E3
Antibody Isotype
IgG2a, Κ
Application
ELISA, ICC, IF, WB

Basic Information

Immunogen
EIF4EBP3 (AAH10881, 1 a.a. - 100 a.a) full-length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 4E Binding Protein 3
Introduction
This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. Among its related pathways are Beta-Adrenergic Signaling and Translation Factors. An important paralog of this gene is EIF4EBP1. Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
Entrez Gene ID
8637
UniProt ID
O60516
Alternative Names
4EBP3; 4E-BP3
Research Area
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
Biological Process
Negative regulation of translational initiation Source: GO_Central
Cellular Location
Cytoplasm; Eukaryotic translation initiation factor 4F complex; Membrane
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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