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Mouse Anti-EIF4EBP3 Recombinant Antibody (CAP685) (CBMAB-AP2041LY)


See all EIF4EBP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CAP685
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant protein of human EIF4EBP3
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 4E Binding Protein 3
Introduction
This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
Entrez Gene ID
Human8637
Mouse108112
UniProt ID
HumanO60516
MouseQ80VV3
Alternative Names
Eukaryotic Translation Initiation Factor 4E Binding Protein 3; EIF4E-Binding Protein 3; 4E-BP3; Eukaryotic Translation Initiation Factor 4E-Binding Protein 3; Eukaryotic Initiation Factor 4E-Binding Protein 3; 4EBP3;
Research Area
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
Biological Process
Negative regulation of translational initiation Source: GO_Central
Cellular Location
Cytoplasm; Eukaryotic translation initiation factor 4F complex; Membrane
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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