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Mouse Anti-EIF4G2 Recombinant Antibody (CBYCD-471) (CBMAB-D2043-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Eukaryotic Translation Initiation Factor 4 Gamma 2 (EIF4G2). The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all EIF4G2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-471
Antibody Isotype
IgG1
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 811-890

Target

Full Name
Eukaryotic Translation Initiation Factor 4 Gamma 2
Introduction
EIF4G2 shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. EIF4G2 functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon.
Entrez Gene ID
1982
UniProt ID
P78344
Alternative Names
Eukaryotic Translation Initiation Factor 4 Gamma 2; Death-Associated Protein 5; EIF-4-Gamma 2; EIF-4G 2; EIF4G 2; DAP-5; DAP5;
Research Area
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Biological Process
Cell death Source: ProtInc
Cellular macromolecule biosynthetic process Source: ParkinsonsUK-UCL
Heart development Source: Ensembl
Negative regulation of autophagy Source: ParkinsonsUK-UCL
Positive regulation of axon extension Source: Ensembl
Positive regulation of cell growth Source: ParkinsonsUK-UCL
Positive regulation of dendritic spine development Source: Ensembl
Positive regulation of translation Source: Ensembl
Regulation of cell cycle Source: ProtInc
Regulation of translational initiation Source: UniProtKB
Cellular Location
Cytosol; Adherens junction; Axon; Eukaryotic translation initiation factor 4F complex; Membrane
PTM
Phosphorylation; hyperphosphorylated during mitosis.

Smirnova, V. V., Shestakova, E. D., Nogina, D. S., Mishchenko, P. A., Prikazchikova, T. A., Zatsepin, T. S., ... & Terenin, I. M. (2022). Ribosomal leaky scanning through a translated uORF requires eIF4G2. Nucleic acids research, 50(2), 1111-1127.

Chen, K., Xi, M., Huang, Q., Wu, H., Lu, G., Song, S., & Shi, W. (2022). Long non-coding RNA MCM3AP antisense RNA 1 silencing upregulates microRNA-24-3p to accelerate proliferation and migration of vascular endothelial cells in myocardial infarction rats by reducing EIF4G2. Cell Cycle, 21(7), 674-684.

Li, S., Shao, J., Lou, G., Wu, C., Liu, Y., & Zheng, M. (2021). MiR-144-3p-mediated dysregulation of EIF4G2 contributes to the development of hepatocellular carcinoma through the ERK pathway. Journal of Experimental & Clinical Cancer Research, 40(1), 1-14.

Zhang, J., Zhang, R., & Ye, Y. (2021). Long non-coding RNA (LncRNA) SNHG7/Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant. Bioengineered, 12(2), 10541-10552.

Zhao, H., Wang, A., & Zhang, Z. (2020). LncRNA SDHAP1 confers paclitaxel resistance of ovarian cancer by regulating EIF4G2 expression via miR-4465. The Journal of Biochemistry, 168(2), 171-181.

Gao, S., Liu, L., Zhu, S., Wang, D., Wu, Q., Ning, G., & Feng, S. (2020). MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2. Bioscience Reports, 40(9).

Wang, J., Lin, Z., Yang, Z., & Liu, X. (2020). lncRNA Eif4g2 improves palmitate-induced dysfunction of mouse β-cells via modulation of Nrf2 activation. Experimental cell research, 396(2), 112291.

Zhang, X., Sun, Z., & Zou, Y. (2020). LncRNA NEAT1 exacerbates non-small cell lung cancer by upregulating EIF4G2 via miR-582-5p sponging. Archives of Biological Sciences, 72(2), 243-252.

Chai, Y., & Xie, M. (2019). LINC01579 promotes cell proliferation by acting as a ceRNA of miR‐139‐5p to upregulate EIF4G2 expression in glioblastoma. Journal of cellular physiology, 234(12), 23658-23666.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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