EIF4G2

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

Eukaryotic Translation Initiation Factor 4 Gamma 2

Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.

Cell death Source: ProtInc
Cellular macromolecule biosynthetic process Source: ParkinsonsUK-UCL
Heart development Source: Ensembl
Negative regulation of autophagy Source: ParkinsonsUK-UCL
Positive regulation of axon extension Source: Ensembl
Positive regulation of cell growth Source: ParkinsonsUK-UCL
Positive regulation of dendritic spine development Source: Ensembl
Positive regulation of translation Source: Ensembl
Regulation of cell cycle Source: ProtInc
Regulation of translational initiation Source: UniProtKB

Cytosol; Adherens junction; Axon; Eukaryotic translation initiation factor 4F complex; Membrane

Phosphorylation; hyperphosphorylated during mitosis.