EIF4G2

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Full Name
Eukaryotic Translation Initiation Factor 4 Gamma 2
Research Area
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Biological Process
Cell death Source: ProtInc
Cellular macromolecule biosynthetic process Source: ParkinsonsUK-UCL
Heart development Source: Ensembl
Negative regulation of autophagy Source: ParkinsonsUK-UCL
Positive regulation of axon extension Source: Ensembl
Positive regulation of cell growth Source: ParkinsonsUK-UCL
Positive regulation of dendritic spine development Source: Ensembl
Positive regulation of translation Source: Ensembl
Regulation of cell cycle Source: ProtInc
Regulation of translational initiation Source: UniProtKB
Cellular Location
Cytosol; Adherens junction; Axon; Eukaryotic translation initiation factor 4F complex; Membrane
PTM
Phosphorylation; hyperphosphorylated during mitosis.
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Anti-EIF4G2 antibodies

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Rabbit Anti-EIF4G2 Recombinant Antibody (D10) (CBMAB-CP0570-LY)

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Target: EIF4G2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D10
Application*: WB, IF
Datasheet SDS

Mouse Anti-EIF4G2 Recombinant Antibody (3B5) (CBMAB-D2042-YC)

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Target: EIF4G2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 3B5
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-EIF4G2 Recombinant Antibody (39) (CBMAB-D2041-YC)

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Target: EIF4G2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 39
Application*: WB, IF, P
Datasheet SDS

Mouse Anti-EIF4G2 Recombinant Antibody (3E4) (V2LY-0425-LY1777)

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Target: EIF4G2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 3E4
Application*: WB, E, IF
Datasheet SDS

Rabbit Anti-EIF4G2 Recombinant Antibody (CBFYE-0741) (V2LY-0425-LY1776)

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Target: EIF4G2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYE-0741
Application*: WB
Datasheet SDS

Mouse Anti-EIF4G2 Recombinant Antibody (CBFYE-0740) (V2LY-0425-LY1775)

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Target: EIF4G2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0740
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-EIF4G2 Recombinant Antibody (CBFYE-0738) (V2LY-0425-LY1774)

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Target: EIF4G2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Cattle, Dog, Pig
Clone: CBFYE-0738
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-EIF4G2 Recombinant Antibody (CBYCD-471) (V2LY-0425-LY1773)

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Target: EIF4G2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Cattle
Clone: CBYCD-471
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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