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Mouse Anti-EIF4H (AA 1-100) Recombinant Antibody (CBFYE-0743) (CBMAB-E1176-FY)

This product is mouse antibody that recognizes EIF4H. The antibody CBFYE-0743 can be used for immunoassay techniques such as: ELISA, WB.
See all EIF4H antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0743
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
WBSCR1 partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-100

Target

Full Name
Eukaryotic Translation Initiation Factor 4H
Introduction
This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.
Entrez Gene ID
7458
UniProt ID
Q15056
Alternative Names
Eukaryotic Translation Initiation Factor 4H; Williams-Beuren Syndrome Chromosome Region 1; WBSCR1; EIF-4H; WSCR1; Williams-Beuren Syndrome Chromosomal Region 1 Protein; KIAA0038
Research Area
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Biological Process
Developmental growth Source: Ensembl
Eukaryotic translation initiation factor 4F complex assembly Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
Regulation of translational initiation Source: ProtInc
Sexual reproduction Source: Ensembl
Cellular Location
Perinuclear region
Involvement in disease
EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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