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Mouse Anti-EIF4H Recombinant Antibody (CBFYE-0746) (CBMAB-E1179-FY)

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Basic Information

Host Animal
Mouse
Clone
CBFYE-0746
Application
WB, IP, IF, ELISA
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Eukaryotic Translation Initiation Factor 4H
Introduction
This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.
Entrez Gene ID
7458
UniProt ID
Q15056
Alternative Names
Eukaryotic Translation Initiation Factor 4H; Williams-Beuren Syndrome Chromosome Region 1; WBSCR1; EIF-4H; WSCR1; Williams-Beuren Syndrome Chromosomal Region 1 Protein; KIAA0038
Research Area
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Biological Process
Developmental growth Source: Ensembl
Eukaryotic translation initiation factor 4F complex assembly Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
Regulation of translational initiation Source: ProtInc
Sexual reproduction Source: Ensembl
Cellular Location
Perinuclear region
Involvement in disease
EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Goodman, L. D., Prudencio, M., Srinivasan, A. R., Rifai, O. M., Lee, V. M. Y., Petrucelli, L., & Bonini, N. M. (2019). eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Acta neuropathologica communications, 7(1), 1-16.

Teo, C. S. H., & O’Hare, P. (2018). A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus. PLoS Pathogens, 14(7), e1007196.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-EIF4H Recombinant Antibody (CBFYE-0746) (CAT#: V2LY-0425-LY1782)

Related Products

Mouse Anti-EIF4H Recombinant Antibody (4B2) (CAT#: CBMAB-A9909-LY)

Rabbit Anti-EIF4H Recombinant Antibody (CBFYE-0745) (CAT#: CBMAB-E1178-FY)

Mouse Anti-EIF4H Recombinant Antibody (CBFYE-0746) (CAT#: V2LY-0425-LY1782)

Rabbit Anti-EIF4H Recombinant Antibody (CBFYE-0745) (CAT#: V2LY-0425-LY1781)

Mouse Anti-EIF4H Recombinant Antibody (4B2) (CAT#: V2LY-0425-LY1783)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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