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Rabbit Anti-EIF4H Recombinant Antibody (CBFYE-0745) (V2LY-0425-LY1781)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBFYE-0745
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Immunogen
Synthetic peptide corresponding to the sequence of human eIF4H.
Host Species
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:1,000
IP1:50
IF(ICC)1:200-1:800

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & Glycerol & HEPES
Preservative
Sodium Azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 4H
Entrez Gene ID
Human7458
Mouse22384
Rat288599
Monkey693429
UniProt ID
HumanQ15056
MouseQ9WUK2
RatQ5XI72
MonkeyF7HNN2
Research Area
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Biological Process
Developmental growth Source: Ensembl
Eukaryotic translation initiation factor 4F complex assembly Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
Regulation of translational initiation Source: ProtInc
Sexual reproduction Source: Ensembl
Cellular Location
Perinuclear region
Involvement in disease
EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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