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EIF4H

This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Full Name
Eukaryotic Translation Initiation Factor 4H
Research Area
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Biological Process
Developmental growth Source: Ensembl
Eukaryotic translation initiation factor 4F complex assembly Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
Regulation of translational initiation Source: ProtInc
Sexual reproduction Source: Ensembl
Cellular Location
Perinuclear region
Involvement in disease
EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
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Anti-EIF4H antibodies

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Mouse Anti-EIF4H Recombinant Antibody (4B2) (V2LY-0425-LY1783)

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Target: EIF4H
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 4B2
Application*: WB, E
Datasheet SDS

Mouse Anti-EIF4H Recombinant Antibody (CBFYE-0746) (V2LY-0425-LY1782)

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Target: EIF4H
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0746
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-EIF4H Recombinant Antibody (CBFYE-0745) (V2LY-0425-LY1781)

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Target: EIF4H
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYE-0745
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-EIF4H Recombinant Antibody (4B2) (CBMAB-A9909-LY)

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Target: EIF4H
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B2
Application*: WB, E
Datasheet SDS

Mouse Anti-EIF4H Recombinant Antibody (CBFYE-0746) (CBMAB-E1179-FY)

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Target: EIF4H
Host: Mouse
Specificity: Human
Clone: CBFYE-0746
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-EIF4H Recombinant Antibody (CBFYE-0745) (CBMAB-E1178-FY)

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Target: EIF4H
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYE-0745
Application*: WB, IP, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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