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  • Mouse Anti-EIF4H Recombinant Antibody (CBFYE-0746)

Mouse Anti-EIF4H Recombinant Antibody (CBFYE-0746) (V2LY-0425-LY1782)

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Basic Information

Host Animal
Mouse
Clone
CBFYE-0746
Application
WB, IP, IF, ELISA
Immunogen
Amino acids 51-201 mapping within an internal region of human Eif4h.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Eukaryotic Translation Initiation Factor 4H
Entrez Gene ID
Human7458
Mouse22384
Rat288599
UniProt ID
HumanQ15056
MouseQ9WUK2
RatQ5XI72
Research Area
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Biological Process
Developmental growth Source: Ensembl
Eukaryotic translation initiation factor 4F complex assembly Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
Regulation of translational initiation Source: ProtInc
Sexual reproduction Source: Ensembl
Cellular Location
Perinuclear region
Involvement in disease
EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Goodman, L. D., Prudencio, M., Srinivasan, A. R., Rifai, O. M., Lee, V. M. Y., Petrucelli, L., & Bonini, N. M. (2019). eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Acta neuropathologica communications, 7(1), 1-16.

Teo, C. S. H., & O’Hare, P. (2018). A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus. PLoS Pathogens, 14(7), e1007196.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-EIF4H Recombinant Antibody (CBFYE-0746) (CAT#: CBMAB-E1179-FY)

Related Products

Mouse Anti-EIF4H Recombinant Antibody (4B2) (CAT#: CBMAB-A9909-LY)

Mouse Anti-EIF4H Recombinant Antibody (CBFYE-0746) (CAT#: CBMAB-E1179-FY)

Rabbit Anti-EIF4H Recombinant Antibody (CBFYE-0745) (CAT#: V2LY-0425-LY1781)

Rabbit Anti-EIF4H Recombinant Antibody (CBFYE-0745) (CAT#: CBMAB-E1178-FY)

Mouse Anti-EIF4H Recombinant Antibody (4B2) (CAT#: V2LY-0425-LY1783)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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