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Mouse Anti-EPS8L2 Recombinant Antibody (6C2) (CBMAB-A2675-LY)

The product is antibody recognizes EPS8L2. The antibody 6C2 immunoassay techniques such as: WB, ELISA.
See all EPS8L2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
6C2
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
EPS8L2 (NP_073609, 615 a.a. ~ 714 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
EPS8-like 2
Introduction
This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq]
Entrez Gene ID
Human64787
Rat361674
UniProt ID
HumanQ9H6S3
RatF7DLY1
Alternative Names
EPS8R2; FLJ16738; FLJ21935; FLJ22171; MGC126530; MGC3088
Research Area
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).
Biological Process
Positive regulation of ruffle assembly Source: UniProtKB
Regulation of catalytic activity Source: GOC
Regulation of Rho protein signal transduction Source: UniProtKB
Rho protein signal transduction Source: UniProtKB
Sensory perception of sound Source: UniProtKB
Cellular Location
Cytoplasm; Stereocilium. Localizes at the tips of the stereocilia of the inner and outer hair cells.
Involvement in disease
Deafness, autosomal recessive, 106 (DFNB106):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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