Mouse Anti-EPS8L2 Recombinant Antibody (CBFYE-0245) (CBMAB-E0499-FY)

Name: Mouse Anti-EPS8L2 Recombinant Antibody (CBFYE-0245)
SKU: CBMAB-E0499-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0245

Application

WB, ELISA, IP

Immunogen

Recombinant human Eps8L2.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Epitope

AA 615-715

More Infomation

Target

Full Name

EPS8-like 2

Introduction

This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling.

Entrez Gene ID

64787

UniProt ID

Q9H6S3

Alternative Names

EPS8 Like 2; Epidermal Growth Factor Receptor Pathway Substrate 8-Related Protein 2; EPS8-Related Protein 2; EPS8R2; Epidermal Growth Factor Receptor Kinase Substrate 8-Like Protein 2; EPS8-Like Protein 2; EPS8-Like 2; DFNB106

Research Area

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).

Biological Process

Positive regulation of ruffle assembly Source: UniProtKB
Regulation of catalytic activity Source: GOC
Regulation of Rho protein signal transduction Source: UniProtKB
Rho protein signal transduction Source: UniProtKB
Sensory perception of sound Source: UniProtKB

Cellular Location

Cytoplasm; Stereocilium. Localizes at the tips of the stereocilia of the inner and outer hair cells.

Involvement in disease

Deafness, autosomal recessive, 106 (DFNB106):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Kawakami, T., Raghavan, V., Ruhe, A. L., Jensen, M. K., Milano, A., Nelson, T. C., & Boyko, A. R. (2022). Early onset adult deafness in the Rhodesian Ridgeback dog is associated with an in-frame deletion in the EPS8L2 gene. PloS one, 17(4), e0264365.

Calero-Cuenca, F. J., Osorio, D. S., Carvalho-Marques, S., Sridhara, S. C., Oliveira, L. M., Jiao, Y., ... & Gomes, E. R. (2021). Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration. Current Biology, 31(7), 1521-1530.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-EPS8L2 Recombinant Antibody (CBFYE-1084) (CAT#: CBMAB-E1618-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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