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EPS8L2

This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq]

Full Name

EPS8-like 2

Research Area

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).

Biological Process

Positive regulation of ruffle assembly Source: UniProtKB
Regulation of catalytic activity Source: GOC
Regulation of Rho protein signal transduction Source: UniProtKB
Rho protein signal transduction Source: UniProtKB
Sensory perception of sound Source: UniProtKB

Cellular Location

Cytoplasm; Stereocilium. Localizes at the tips of the stereocilia of the inner and outer hair cells.

Involvement in disease

Deafness, autosomal recessive, 106 (DFNB106):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Anti-EPS8L2 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-EPS8L2 Recombinant Antibody (6C2) (CBMAB-A2675-LY)

SDS

Target: EPS8L2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Rat

Clone: 6C2

Application*: WB, E

Mouse Anti-EPS8L2 Recombinant Antibody (CBFYE-1084) (CBMAB-E1618-FY)

SDS

Target: EPS8L2

Host: Mouse

Specificity: Human

Clone: CBFYE-1084

Application*: WB, IP, IF, E

Mouse Anti-EPS8L2 (AA 615-715) Recombinant Antibody (CBFYE-0245) (CBMAB-E0499-FY)

SDS

Target: EPS8L2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-0245

Application*: E, WB

Rabbit Anti-EPS8L2 Recombinant Antibody (EG1145) (CBMAB-EN1365-LY)

SDS

Target: EPS8L2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: EG1145

Application*: WB: 1:500~1:1000 ELISA: 1:40000

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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