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Rabbit Anti-EPS8L2 Recombinant Antibody (EG1145) (CBMAB-EN1365-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG1145
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human ES8L2.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
EPS8-like 2
Entrez Gene ID
Human64787
Mouse98845
UniProt ID
HumanQ9H6S3
MouseQ99K30
Research Area
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).
Biological Process
Positive regulation of ruffle assembly Source: UniProtKB
Regulation of catalytic activity Source: GOC
Regulation of Rho protein signal transduction Source: UniProtKB
Rho protein signal transduction Source: UniProtKB
Sensory perception of sound Source: UniProtKB
Cellular Location
Cytoplasm; Stereocilium. Localizes at the tips of the stereocilia of the inner and outer hair cells.
Involvement in disease
Deafness, autosomal recessive, 106 (DFNB106):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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