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Mouse Anti-EXOC3 Recombinant Antibody (4A7) (CBMAB-A2748-LY)

The product is antibody recognizes EXOC3. The antibody 4A7 immunoassay techniques such as: WB, ELISA.
See all EXOC3 antibodies
Published Data
Fig. 1 Western blot
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Fig. 2 Cells were immunostained for Sec6 (green).
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4A7
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
EXOC3 (NP_009208, 646 a.a. ~ 745 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
exocyst complex component 3
Introduction
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq]
Entrez Gene ID
11336
UniProt ID
O60645
Alternative Names
SEC6; SEC6L1; Sec6p
Research Area
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Biological Process
Exocyst localization Source: GO_Central
Exocytosis Source: GO_Central
Protein transport Source: UniProtKB-KW
Cellular Location
Cytoplasm; Golgi apparatus; Perinuclear region; Growth cone; Midbody; Neuron projection. Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). During mitosis, early recruitment to the midbody requires RALA, but not RALB, and EXOC2. In late stages of cytokinesis, localization to the midbody is RALB-dependent (PubMed:18756269).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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