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  • Mouse Anti-FGFR1OP2 Recombinant Antibody (CBXF-0615)

Mouse Anti-FGFR1OP2 Recombinant Antibody (CBXF-0615) (CBMAB-F2674-CQ)

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Basic Information

Host Animal
Mouse
Clone
CBXF-0615
Application
WB, ELISA
Immunogen
Recombinant protein between 1-172 amino acids of human FGFR1OP2
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
FGFR1 oncogene partner 2
Introduction
FGFR1OP2 (FGFR1 Oncogene Partner 2) is a Protein Coding gene. Diseases associated with FGFR1OP2 include 8P11 Myeloproliferative Syndrome. Among its related pathways are VEGF Signaling Pathway and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is SIKE1.
Entrez Gene ID
Human26127
Mouse67529
UniProt ID
HumanQ9NVK5
MouseQ9CRA9
Alternative Names
FGFR1 Oncogene Partner 2; Fibroblast Growth Factor Receptor 1 Oncogene Partner 2; Wound Inducible Transcript 3.0; HSPC123-Like; WIT3.0;
Function
May be involved in wound healing pathway.
Biological Process
Response to wounding Source: GO_Central
Wound healing Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.

Yang, Y., Zhang, E., Huang, H., & Cai, Z. (2022). FGFR1OP2 Promotes Proliferation and Survival of Myeloma Cells and Is a Potential Therapeutic Target. Blood, 140(Supplement 1), 12464-12465.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Mouse Anti-FGFR1OP2 Recombinant Antibody (2G4) (CAT#: CBMAB-A2953-LY)

Mouse Anti-FGFR1OP2 (AA 62-170) Recombinant Antibody (CBXF-0613) (CAT#: CBMAB-F0410-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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