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Mouse Anti-FGFR1OP2 (AA 62-170) Recombinant Antibody (CBXF-0613) (CBMAB-F0410-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0613
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 62-170

Target

Full Name
FGFR1 oncogene partner 2
Introduction
FGFR1OP2 (FGFR1 Oncogene Partner 2) is a Protein Coding gene. Diseases associated with FGFR1OP2 include 8P11 Myeloproliferative Syndrome. Among its related pathways are VEGF Signaling Pathway and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is SIKE1.
Entrez Gene ID
26127
UniProt ID
Q9NVK5
Alternative Names
FGFR1 Oncogene Partner 2; Fibroblast Growth Factor Receptor 1 Oncogene Partner 2; Wound Inducible Transcript 3.0; HSPC123-Like; WIT3.0;
Function
May be involved in wound healing pathway.
Biological Process
Response to wounding Source: GO_Central
Wound healing Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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