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Rabbit Anti-FHL2 Recombinant Antibody (CBXF-1148) (CBMAB-F0898-CQ)

This product is a rabbit antibody that recognizes FHL2. The antibody CBXF-1148 can be used for immunoassay techniques such as: WB, IP, IF.
See all FHL2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1148
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibrinogen Like 2
Introduction
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified.
Entrez Gene ID
Human2274
Mouse14200
Rat63839
UniProt ID
HumanQ14192
MouseO70433
RatO35115
Alternative Names
Four And A Half LIM Domains 2; Skeletal Muscle LIM-Protein 3; LIM Domain Protein DRAL; SLIM-3; FHL-2; SLIM3;
Function
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).
Biological Process
Atrial cardiac muscle cell development Source: Ensembl
Heart trabecula formation Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Osteoblast differentiation Source: Ensembl
Response to hormone Source: BHF-UCL
Ventricular cardiac muscle cell development Source: Ensembl
Cellular Location
Cytoplasm; Nucleus; Z line

Algaber, A., Madhi, R., Hawez, A., Rönnow, C. F., & Rahman, M. (2021). Targeting FHL2‑E‑cadherin axis by miR‑340‑5p attenuates colon cancer cell migration and invasion. Oncology Letters, 22(2), 1-11.

Clemente-Olivo, M. P., Habibe, J. J., Vos, M., Ottenhoff, R., Jongejan, A., Herrema, H., ... & de Vries, C. J. (2021). Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity. Metabolism, 121, 154815.

Habibe, J. J., Clemente-Olivo, M. P., & de Vries, C. J. (2021). How (Epi) Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease. Cells, 10(10), 2611.

Sommer, J., & Hellerbrand, C. (2020). Expression and Function of Four-and-a-Half LIM-domain protein 2 (FHL2) in Hepatocellular Carcinoma. Zeitschrift für Gastroenterologie, 58(01), 4-18.

Wang, C., Lv, X., He, C., Davis, J. S., Wang, C., & Hua, G. (2020). Four and a half lim domains 2 (FHL2) contribute to the epithelial ovarian cancer carcinogenesis. International journal of molecular sciences, 21(20), 7751.

Sommer, J., Dorn, C., Gäbele, E., Bataille, F., Freese, K., Seitz, T., ... & Hellerbrand, C. (2020). Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury. Cells, 9(1), 248.

Zhang, L., Li, R., Chen, L., Xing, Z., Song, Y., Nie, X., ... & Tian, S. (2020). Expression, location and biological effects of four and a half LIM domain protein 2 (FHL2) on granulosa cells in ovine. Reproduction in Domestic Animals, 55(6), 737-746.

Sommer, J., Dorn, C., Weiskirchen, R., & Hellerbrand, C. (2020). Expression and Function of Four-and-a-Half LIM-domain protein 2 (FHL2) in Hepatic Fibrosis. Zeitschrift für Gastroenterologie, 58(01), 1-7.

Nishikawa, M., Sato, K., Nakano, S., Yamakawa, H., Nagase, T., & Ueda, H. (2019). Specific activation of PLEKHG2-induced serum response element-dependent gene transcription by four-and-a-half LIM domains (FHL) 1, but not FHL2 or FHL3. Small GTPases, 10(5), 361-366.

Liang, Y., Bradford, W. H., Zhang, J., & Sheikh, F. (2018). Four and a half LIM domain protein signaling and cardiomyopathy. Biophysical reviews, 10(4), 1073-1085.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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