FHL2

The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]

Full Name

Fibrinogen Like 2

Function

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).

Biological Process

Atrial cardiac muscle cell development Source: Ensembl
Heart trabecula formation Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Osteoblast differentiation Source: Ensembl
Response to hormone Source: BHF-UCL
Ventricular cardiac muscle cell development Source: Ensembl

Cellular Location

Cytoplasm; Nucleus; Z line