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Mouse Anti-MYL12B Recombinant Antibody (1B22) (CBMAB-A5580-LY)

The product is antibody recognizes MRLC2. The antibody 1B22 immunoassay techniques such as: sELISA, ELISA.
See all MYL12B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B22
Antibody Isotype
IgG1, κ
Application
sELISA, ELISA

Basic Information

Immunogen
MRLC2 (NP_291024.1, 73 a.a. ~ 172 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MYOSIN LIGHT CHAIN 12B
Introduction
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM
Entrez Gene ID
103910
UniProt ID
O14950
Alternative Names
MLC-B
Function
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
Biological Process
Regulation of cell shape Source: Ensembl
Cellular Location
Cytoskeleton
myosin II complex
stress fiber
Cytosol
extracellular exosome
Other locations
apical part of cell
brush border
cell cortex
cytoplasm
myofibril
Z disc
PTM
Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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