MYL12B

The activity of nonmuscle myosin II is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments.
Full Name
MYOSIN LIGHT CHAIN 12B
Function
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
Biological Process
Regulation of cell shape Source: Ensembl
Cellular Location
Cytoskeleton
myosin II complex
stress fiber
Cytosol
extracellular exosome
Other locations
apical part of cell
brush border
cell cortex
cytoplasm
myofibril
Z disc
PTM
Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment.
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Anti-MYL12B antibodies

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Mouse Anti-MYL12B Recombinant Antibody (1B22) (CBMAB-A5580-LY)

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Target: MYL12B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B22
Application*: SE, E
Datasheet SDS

Mouse Anti-MYL12B Recombinant Antibody (CBFYM-2950) (CBMAB-M3145-FY)

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Target: MYL12B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2950
Application*: E, WB
Datasheet SDS

Mouse Anti-MYL12B Recombinant Antibody (CBFYM-0720) (CBMAB-M0862-FY)

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Target: MYL12B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0720
Application*: E
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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