Mouse Anti-MYL12B Recombinant Antibody (CBFYM-2950) (CBMAB-M3145-FY)

Name: Mouse Anti-MYL12B Recombinant Antibody (CBFYM-2950)
SKU: CBMAB-M3145-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYM-2950

Application

ELISA, WB

Immunogen

Recombinant protein corresponding to full length MRLC2

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MYOSIN LIGHT CHAIN 12B

Introduction

The activity of nonmuscle myosin II is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments.

Entrez Gene ID

103910

UniProt ID

O14950

Alternative Names

Myosin Light Chain 12B; Myosin Regulatory Light Chain 2-B, Smooth Muscle Isoform; Myosin Regulatory Light Chain 20 KDa; Myosin, Light Chain 12B, Regulatory; Myosin Regulatory Light Chain MRLC2; Myosin Regulatory Light Chain 2; SHUJUN-1; MLC-2A

Function

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.

Biological Process

Regulation of cell shape Source: Ensembl

Cellular Location

Cytoskeleton
myosin II complex
stress fiber
Cytosol
extracellular exosome
Other locations
apical part of cell
brush border
cell cortex
cytoplasm
myofibril
Z disc

PTM

Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-MYL12B Recombinant Antibody (CBFYM-0720) (CAT#: CBMAB-M0862-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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