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Rabbit Anti-PLXNB2 Recombinant Antibody (EPR9965) (CBMAB-1672-CN)

This product is a rabbit antibody that recognizes PLXNB2 of human. The antibody EPR9965 can be used for immunoassay techniques such as: FC, WB.
See all PLXNB2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR9965
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
Synthetic peptide within Human Plexin B2 aa. 1250-1350.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
59% PBS, 40% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Plexin B2
Introduction
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]). Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. This protein plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. This protein plays a role in axon guidance, invasive growth and cell migration.
Entrez Gene ID
Human23654
Mouse140570
Rat315217
UniProt ID
HumanO15031
MouseB2RXS4
RatD3ZQ57
Alternative Names
MM1; PLEXB2; Nbla00445; dJ402G11.3
Function
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity).
Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity).
Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity).
Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity).
Regulates the migration of cerebellar granule cells in the developing brain (By similarity).
Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458).
Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888).
May modulate the activity of RAC1 and CDC42 (By similarity).
Biological Process
Brain developmentISS:UniProtKB
Excitatory synapse assemblyISS:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neural tube closureISS:UniProtKB
Neuroblast proliferationISS:UniProtKB
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Positive regulation of translationManual Assertion Based On ExperimentIMP:CACAO
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeISS:UniProtKB
Regulation of GTPase activityISS:UniProtKB
Regulation of neuron migrationISS:UniProtKB
Regulation of protein phosphorylationISS:UniProtKB
Semaphorin-plexin signaling pathwayISS:UniProtKB
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 20-1197
Helical: 1198-1218
Cytoplasmic: 1219-1838
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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