PLXNB2

PLXNB2 (Plexin B2) is a protein coding gene. Among its related pathways are Axon guidance. Gene Ontology annotations related to this gene include semaphorin receptor activity. An important paralog of the gene is PLXNB1.

Full Name

Plexin B2

Function

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity).
Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity).
Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity).
Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity).
Regulates the migration of cerebellar granule cells in the developing brain (By similarity).
Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458).
Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888).
May modulate the activity of RAC1 and CDC42 (By similarity).

Biological Process

Brain developmentISS:UniProtKB
Excitatory synapse assemblyISS:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neural tube closureISS:UniProtKB
Neuroblast proliferationISS:UniProtKB
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Positive regulation of translationManual Assertion Based On ExperimentIMP:CACAO
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeISS:UniProtKB
Regulation of GTPase activityISS:UniProtKB
Regulation of neuron migrationISS:UniProtKB
Regulation of protein phosphorylationISS:UniProtKB
Semaphorin-plexin signaling pathwayISS:UniProtKB
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 20-1197
Helical: 1198-1218
Cytoplasmic: 1219-1838