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Mouse Anti-PLXNB2 Recombinant Antibody (2H3) (CBMAB-P2205-YC)

Provided herein is a Mouse monoclonal antibody against Human Plexin B2. The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all PLXNB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2H3
Antibody Isotype
IgG2b, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
PLXNB2 (AAH04542, 1-470 aa) full length recombinant protein with GST tag. Immunogen sequence: MHTLFLELLE QYVVAKNPKL MLRRSETVVE RMLSNWMSIC LYQYLKDSAG EPLYKLFKAI KHQVEKGPVD AVQKKAKYTL NDTGLLGDDV EYAPLTVSVI VQDEGVDAIP VKVLNCDTIS QVKEKIIDQV YRGQPCSCWP RPDSVVLEWR PGSTAQILSD LDLTSQQEGR WKRVNTLMHY NVRDGATLIL SKVGVSQQPE DSQQDLPGER HALLEEENRV WHLVRPTDEV DEGKSKRGSV KEKERTKAIT EIYLTRLLSV KGTLQQFVDN FFQSVLAPGH AVPPAVKYFF DFLDEQAEKH NIQDEDTIHI WKTNSLPLRF WVNILKNPHF IFDVHVHEVV DASLSVIAQT FMDACTRTEH KLSRDSPSNK LLYAKEISTY KKMVEDYYKG IRQMVQVSDQ DMNTHLAEIS RAHTDSLNTL VALHQLYQYT QKYYDEIINA LEEDPAAQKM QLAFRLQQIA AALENKVTDL
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-470

Target

Full Name
Plexin B2
Introduction
PLXNB2 (Plexin B2) is a protein coding gene. Among its related pathways are Axon guidance. Gene Ontology annotations related to this gene include semaphorin receptor activity. An important paralog of the gene is PLXNB1.
Entrez Gene ID
23654
UniProt ID
O15031
Alternative Names
MM1; dJ402G11.3; Nbla00445; plexin-B2; Debt; PLEXB2
Function
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity).
Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity).
Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity).
Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity).
Regulates the migration of cerebellar granule cells in the developing brain (By similarity).
Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458).
Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888).
May modulate the activity of RAC1 and CDC42 (By similarity).
Biological Process
Brain developmentISS:UniProtKB
Excitatory synapse assemblyISS:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neural tube closureISS:UniProtKB
Neuroblast proliferationISS:UniProtKB
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Positive regulation of translationManual Assertion Based On ExperimentIMP:CACAO
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeISS:UniProtKB
Regulation of GTPase activityISS:UniProtKB
Regulation of neuron migrationISS:UniProtKB
Regulation of protein phosphorylationISS:UniProtKB
Semaphorin-plexin signaling pathwayISS:UniProtKB
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 20-1197
Helical: 1198-1218
Cytoplasmic: 1219-1838
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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