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Rabbit Anti-RCAN1 Recombinant Antibody (EPR8911) (CBMAB-1755-CN)

This product is a rabbit antibody that recognizes RCAN1 of human. The antibody EPR8911 can be used for immunoassay techniques such as: WB.
See all RCAN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR8911
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Regulator Of Calcineurin 1
Introduction
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. It could play a role during central nervous system development.
Entrez Gene ID
Human1827
Mouse54720
Rat266766
UniProt ID
HumanP53805
MouseQ9JHG6
RatQ6IN33
Alternative Names
CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78
Function
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556).
Could play a role during central nervous system development (By similarity).
Biological Process
Biological Process calcineurin-NFAT signaling cascadeIEA:Ensembl
Biological Process calcium-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process locomotion involved in locomotory behaviorIEA:Ensembl
Biological Process negative regulation of calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of phosphoprotein phosphatase activityIEA:Ensembl
Biological Process response to ischemiaIEA:Ensembl
Biological Process response to oxidative stressIEA:Ensembl
Biological Process short-term memoryIEA:Ensembl
Biological Process skeletal muscle fiber developmentIEA:Ensembl
Cellular Location
cytoplasm
nucleus
PTM
Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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