RCAN1

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Full Name

Regulator Of Calcineurin 1

Function

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556).
Could play a role during central nervous system development (By similarity).

Biological Process

Biological Process calcineurin-NFAT signaling cascadeIEA:Ensembl
Biological Process calcium-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process locomotion involved in locomotory behaviorIEA:Ensembl
Biological Process negative regulation of calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of phosphoprotein phosphatase activityIEA:Ensembl
Biological Process response to ischemiaIEA:Ensembl
Biological Process response to oxidative stressIEA:Ensembl
Biological Process short-term memoryIEA:Ensembl
Biological Process skeletal muscle fiber developmentIEA:Ensembl

Cellular Location

cytoplasm
nucleus

PTM

Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.