Mouse Anti-RCAN1 Recombinant Antibody (4D9-G3) (CBMAB-R1916-CN)

Name: Mouse Anti-RCAN1 Recombinant Antibody (4D9-G3)
SKU: CBMAB-R1916-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4D9-G3

Application

ELISA

Immunogen

RCN1 (H10120, aa. 31-331) full-length recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Preservative

No preservatives

More Infomation

Target

Full Name

Regulator Of Calcineurin 1

Introduction

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Entrez Gene ID

1827

UniProt ID

P53805

Alternative Names

Regulator Of Calcineurin 1; Myocyte-Enriched Calcineurin-Interacting Protein 1; Down Syndrome Critical Region Gene 1; ADAPT78; DSCR1; MCIP1; DSC1; CSP1;

Function

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556).
Could play a role during central nervous system development (By similarity).

Biological Process

Biological Process calcineurin-NFAT signaling cascadeIEA:Ensembl
Biological Process calcium-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process locomotion involved in locomotory behaviorIEA:Ensembl
Biological Process negative regulation of calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of phosphoprotein phosphatase activityIEA:Ensembl
Biological Process response to ischemiaIEA:Ensembl
Biological Process response to oxidative stressIEA:Ensembl
Biological Process short-term memoryIEA:Ensembl
Biological Process skeletal muscle fiber developmentIEA:Ensembl

Cellular Location

cytoplasm
nucleus

PTM

Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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