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Mouse Anti-RCAN1 Recombinant Antibody (4D9-G3) (CBMAB-R1916-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4D9-G3
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
RCN1 (H10120, aa. 31-331) full-length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
No preservatives

Target

Full Name
Regulator Of Calcineurin 1
Introduction
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Entrez Gene ID
1827
UniProt ID
P53805
Alternative Names
Regulator Of Calcineurin 1; Myocyte-Enriched Calcineurin-Interacting Protein 1; Down Syndrome Critical Region Gene 1; ADAPT78; DSCR1; MCIP1; DSC1; CSP1;
Function
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556).
Could play a role during central nervous system development (By similarity).
Biological Process
Biological Process calcineurin-NFAT signaling cascadeIEA:Ensembl
Biological Process calcium-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process locomotion involved in locomotory behaviorIEA:Ensembl
Biological Process negative regulation of calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of phosphoprotein phosphatase activityIEA:Ensembl
Biological Process response to ischemiaIEA:Ensembl
Biological Process response to oxidative stressIEA:Ensembl
Biological Process short-term memoryIEA:Ensembl
Biological Process skeletal muscle fiber developmentIEA:Ensembl
Cellular Location
cytoplasm
nucleus
PTM
Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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