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Rabbit Anti-RNLS Recombinant Antibody (EPR4212(2)) (CBMAB-1776-CN)

This product is a rabbit antibody that recognizes RNLS of human. The antibody EPR4212(2) can be used for immunoassay techniques such as: IHC-P, WB.
See all RNLS antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR4212(2)
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
Synthetic peptide within Human Renalase aa. 50-150.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Renalase, FAD Dependent Amine Oxidase
Introduction
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney. The protein catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Entrez Gene ID
Human55328
Mouse67795
Rat361751
UniProt ID
HumanQ5VYX0
MouseA7RDN6
RatQ5U2W9
Alternative Names
C10orf59; RENALASE
Function
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Biological Process
Biological Process negative regulation of blood pressureManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of heart rateManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to epinephrineIEA:Ensembl
Biological Process response to ischemiaIEA:Ensembl
Biological Process response to saltIEA:Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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