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Mouse Anti-RNLS Recombinant Antibody (1C11E8) (CBMAB-R0219-CN)

This product is a Mouse antibody that recognizes RNLS. The antibody 1C11E8 can be used for immunoassay techniques such as: WB, FC, ELISA, IHC, ICC, CyTOF.
See all RNLS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C11E8
Antibody Isotype
IgG1
Application
WB, FC, ELISA, IHC, ICC, CyTOF

Basic Information

Immunogen
Purified recombinant fragment of human RNLS (aa. 68-242) expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Renalase, FAD Dependent Amine Oxidase
Introduction
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]). [supplied by OMIM, Mar 2008]
Entrez Gene ID
55328
UniProt ID
Q5VYX0
Alternative Names
Renalase, FAD Dependent Amine Oxidase; Monoamine Oxidase-C; C10orf59; MAO-C; Chromosome 10 Open Reading Frame 59; Alpha-NAD(P)H Oxidase/Anomerase; EC 1.6.3.5; RENALASE;
Function
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Biological Process
Biological Process negative regulation of blood pressureManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of heart rateManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to epinephrineIEA:Ensembl
Biological Process response to ischemiaIEA:Ensembl
Biological Process response to saltIEA:Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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