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RNLS

Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

Full Name

Renalase, FAD Dependent Amine Oxidase

Function

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

Biological Process

Biological Process negative regulation of blood pressureManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of heart rateManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to epinephrineIEA:Ensembl
Biological Process response to ischemiaIEA:Ensembl
Biological Process response to saltIEA:Ensembl

Cellular Location

Secreted

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Anti-RNLS antibodies

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Mouse Anti-RNLS Recombinant Antibody (CBT2911) (V2LY-0625-LY426)

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Target: RNLS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2911

Application*: WB

Mouse Anti-RNLS Recombinant Antibody (CF369) (CBMAB-FT141LY)

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Target: RNLS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CF369

Application*: ELISA, WB, IHC

Mouse Anti-RNLS Recombinant Antibody (CBXC-0688) (CBMAB-C5433-CQ)

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Target: RNLS

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXC-0688

Application*: WB, SE, IR, E

Mouse Anti-RNLS Recombinant Antibody (CBYY-C3121) (CBMAB-C4564-YY)

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Target: RNLS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C3121

Application*: E, WB, IH

Mouse Anti-RNLS Recombinant Antibody (CBFYM-3092) (CBMAB-M3288-FY)

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Target: RNLS

Host: Mouse

Specificity: Rat

Clone: CBFYM-3092

Application*: WB, IC, P, C, E

Mouse Anti-RNLS Recombinant Antibody (CBFYM-3091) (CBMAB-M3287-FY)

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Target: RNLS

Host: Mouse

Specificity: Human

Clone: CBFYM-3091

Application*: WB, IC, P, C, E

Mouse Anti-RNLS Recombinant Antibody (3A12F5) (CBMAB-C5634-LY)

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Target: RNLS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3A12F5

Application*: E, WB, IH

Mouse Anti-RNLS Recombinant Antibody (1C11E8) (CBMAB-R0219-CN)

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Target: RNLS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1C11E8

Application*: WB, F, E, IH, ICC, MC

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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