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Rabbit Anti-RTN4RL1 Recombinant Antibody (EPR11334) (CBMAB-1785-CN)

This product is a rabbit antibody that recognizes RTN4RL1 of human. The antibody EPR11334 can be used for immunoassay techniques such as: FC, IF, WB.
See all RTN4RL1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR11334
Antibody Isotype
IgG
Application
FC, IF, WB

Basic Information

Immunogen
Synthetic peptide within Human RTN4RL1 aa. 350 to the C-terminus (Cysteine residue).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Reticulon 4 Receptor Like 1
Introduction
Cell surface receptor. This protein plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. This protein plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).
Entrez Gene ID
Human146760
Mouse237847
Rat303311
UniProt ID
HumanQ86UN2
MouseQ8K0S5
RatQ80WD0
Alternative Names
NgR3; NGRH2
Function
Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity).
Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).
Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
Biological Process
Biological Process axon regenerationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process corpus callosum developmentIEA:Ensembl
Biological Process negative regulation of axon regenerationISS:UniProtKB
Biological Process negative regulation of neuron projection developmentISS:UniProtKB
Cellular Location
Cell membrane
Membrane raft
Perikaryon
Cell projection
Localized to the surface of neurons, including axons.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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