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Mouse Anti-RTN4RL1 Recombinant Antibody (CBWJN-1667) (CBMAB-N4236-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1667
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Reticulon 4 Receptor Like 1
Introduction
RTN4RL1 (Reticulon 4 Receptor Like 1) is a Protein Coding gene. Diseases associated with RTN4RL1 include Retrograde Amnesia. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include receptor activity. An important paralog of this gene is RTN4RL2.
Entrez Gene ID
146760
UniProt ID
Q86UN2
Alternative Names
Reticulon 4 Receptor Like 1; Nogo-66 Receptor Homolog 2; Nogo-66 Receptor-Related Protein 3; Nogo Receptor-Like 2; NGRH2; NgR3; Reticulon 4 Receptor-Like 1; Reticulon-4 Receptor-Like 1; NGRL2;
Function
Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity).
Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).
Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
Biological Process
Biological Process axon regenerationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process corpus callosum developmentIEA:Ensembl
Biological Process negative regulation of axon regenerationISS:UniProtKB
Biological Process negative regulation of neuron projection developmentISS:UniProtKB
Cellular Location
Cell membrane
Membrane raft
Perikaryon
Cell projection
Localized to the surface of neurons, including axons.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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