Human Recombinant RTN4RL1 protein, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY6632)

Name: Human Recombinant RTN4RL1 protein, Biotin Conjugated, His & AVI Tag
SKU: V2LY-0526-LY6632
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & AVI Tag

Protein Construction

This product is Human Recombinant RTN4RL1 protein, Biotin Conjugated, His & AVI Tag consist of Amino Acid: 1-419 and predicts a molecular mass of 47.72 kDa.

Molecule Mass

47.72 kDa

Verified

HPLC

Conjugates

Biotin

Sequence

Amino Acid: 1-419

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Reticulon 4 Receptor Like 1

Function

Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity).
Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).
Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).

Biological Process

Biological Process axon regenerationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process corpus callosum developmentIEA:Ensembl
Biological Process negative regulation of axon regenerationISS:UniProtKB
Biological Process negative regulation of neuron projection developmentISS:UniProtKB

Cellular Location

Cell membrane
Membrane raft
Perikaryon
Cell projection
Localized to the surface of neurons, including axons.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant RTN4RL1 protein, hFc Tag (CAT#: V2LY-0526-LY6631)

Related Products

Human Recombinant RTN4RL1 protein, hFc Tag (CAT#: V2LY-0526-LY6631)

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Mouse Anti-RTN4RL1 Recombinant Antibody (B-7) (CAT#: CBMAB-N4237-WJ)

Mouse Anti-RTN4RL1 Recombinant Antibody (H-11) (CAT#: CBMAB-N4238-WJ)

Mouse Anti-RTN4RL1 Recombinant Antibody (CBWJN-1667) (CAT#: CBMAB-N4236-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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