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Mouse Anti-STK16 Recombinant Antibody (CBXS-6120) (CBMAB-S2955-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-6120
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant human STK16 (1-305aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
STK16
Introduction
STK16 (Serine/Threonine Kinase 16) is a Protein Coding gene. Diseases associated with STK16 include Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia and Diffuse Mesangial Sclerosis. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
Entrez Gene ID
8576
UniProt ID
O75716
Alternative Names
KRCT; MPSK; PKL12; PSK; TSF1; hPSK
Function
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
Biological Process
Biological Process cellular response to transforming growth factor beta stimulusIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, perinuclear region
Membrane
Associates with Golgi and Golgi-derived vesicles.
PTM
Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198.
It is uncertain whether palmitoylation is on Cys-6 and/or Cys-8.
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For research use only. Not intended for any clinical use.

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