ADRA1B

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of whi

Full Name

Adrenoceptor Alpha 1B

Function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

Biological Process

Adenylate cyclase-activating adrenergic receptor signaling pathway
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Cell-cell signaling
G protein-coupled receptor signaling pathway
Intracellular signal transduction
Neuron-glial cell signaling
Phospholipase C-activating G protein-coupled receptor signaling pathway
Positive regulation of cytosolic calcium ion concentration
Positive regulation of heart rate by epinephrine-norepinephrine
Positive regulation of MAPK cascade
Positive regulation of vasoconstriction
Regulation of cardiac muscle contraction

Cellular Location

Cytoplasm; Cell membrane; Nucleus membrane; Caveola. Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Topology

Extracellular: 1-45 aa
Helical: 46-70 aa
Cytoplasmic: 71-83 aa
Helical: 84-105 aa
Extracellular: 106-115 aa
Helical: 116-141 aa
Cytoplasmic: 142-161 aa
Helical: 162-184 aa
Extracellular: 185-201 aa
Helical: 202-224 aa
Cytoplasmic: 225-295 aa
Helical: 296-319 aa
Extracellular: 320-326 aa
Helical: 327-351 aa
Cytoplasmic: 352-520 aa