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Mouse Anti-ADRA1B Recombinant Antibody (V2-180021) (CBMAB-A1414-YC)

Provided herein is a Mouse monoclonal antibody against Human Adrenoceptor Alpha 1B. The antibody can be used for immunoassay techniques, such as FC.
See all ADRA1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180021
Antibody Isotype
IgG2b
Application
IHC-F

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human ADRA1B Met1-Phe520.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC0.25 μg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adrenoceptor Alpha 1B
Introduction
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of whi
Entrez Gene ID
147
UniProt ID
P35368
Alternative Names
Adrenoceptor Alpha 1B; Adrenergic, Alpha-1B-, Receptor; Alpha-1B Adrenoreceptor; Alpha-1B Adrenoceptor; Alpha-1B Adrenergic Receptor; ALPHA1BAR; ADRA1;
Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Biological Process
Adenylate cyclase-activating adrenergic receptor signaling pathway
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Cell-cell signaling
G protein-coupled receptor signaling pathway
Intracellular signal transduction
Neuron-glial cell signaling
Phospholipase C-activating G protein-coupled receptor signaling pathway
Positive regulation of cytosolic calcium ion concentration
Positive regulation of heart rate by epinephrine-norepinephrine
Positive regulation of MAPK cascade
Positive regulation of vasoconstriction
Regulation of cardiac muscle contraction
Cellular Location
Cytoplasm; Cell membrane; Nucleus membrane; Caveola. Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
Topology
Extracellular: 1-45 aa
Helical: 46-70 aa
Cytoplasmic: 71-83 aa
Helical: 84-105 aa
Extracellular: 106-115 aa
Helical: 116-141 aa
Cytoplasmic: 142-161 aa
Helical: 162-184 aa
Extracellular: 185-201 aa
Helical: 202-224 aa
Cytoplasmic: 225-295 aa
Helical: 296-319 aa
Extracellular: 320-326 aa
Helical: 327-351 aa
Cytoplasmic: 352-520 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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